A high tissue-to-plasma partition coefficient (Kp) indicates tissue concentration is:

A high tissue-to-plasma partition coefficient (Kp) indicates tissue concentration is:

• A. Lower than plasma
• B. Equal to plasma
• C. Higher than plasma
• D. Not related to tissue perfusion

Answer: (C)

The tissue-to-plasma partition coefficient, Kp, is the ratio of drug concentration in tissue to that in plasma at equilibrium. A high Kp means the tissue concentration is higher than the plasma concentration, indicating the drug distributes into and accumulates in tissue more than in plasma. This reflects how well the drug partitions into tissue relative to staying in the blood, influenced by factors like lipophilicity and tissue binding. For example, if plasma is 2 mg/L and tissue is 6 mg/L, Kp would be 3, showing tissue-rich distribution. If Kp is around 1, tissue and plasma concentrations are similar; if below 1, tissue concentration is lower than plasma. Perfusion affects how quickly equilibrium is reached but not the ratio itself at equilibrium.

The tissue-to-plasma partition coefficient, Kp, is the ratio of drug concentration in tissue to that in plasma at equilibrium. A high Kp means the tissue concentration is higher than the plasma concentration, indicating the drug distributes into and accumulates in tissue more than in plasma. This reflects how well the drug partitions into tissue relative to staying in the blood, influenced by factors like lipophilicity and tissue binding. For example, if plasma is 2 mg/L and tissue is 6 mg/L, Kp would be 3, showing tissue-rich distribution. If Kp is around 1, tissue and plasma concentrations are similar; if below 1, tissue concentration is lower than plasma. Perfusion affects how quickly equilibrium is reached but not the ratio itself at equilibrium.