Dissolution is defined as which process?

Dissolution is defined as which process?

• A. Process by which a drug moves from solid state into solute
• B. Conjugation to attach a polar moiety
• C. Transport across membranes by carrier proteins
• D. Binding to plasma proteins to prolong circulation

Answer: (A)

Dissolution is the process by which a solid drug substance dissolves in a solvent to form a solution, making the drug available for absorption. In practice, a solid dosage form must first disintegrate and then dissolve so that the drug molecules can be carried into solution and taken up by the body. The rate of dissolution depends on factors like solubility, particle size, surface area, agitation, and the composition of the dissolution medium. This concept is distinct from chemical modification of the drug (conjugation), transport across membranes (permeation), or binding to plasma proteins (distribution).

Dissolution is the process by which a solid drug substance dissolves in a solvent to form a solution, making the drug available for absorption. In practice, a solid dosage form must first disintegrate and then dissolve so that the drug molecules can be carried into solution and taken up by the body. The rate of dissolution depends on factors like solubility, particle size, surface area, agitation, and the composition of the dissolution medium. This concept is distinct from chemical modification of the drug (conjugation), transport across membranes (permeation), or binding to plasma proteins (distribution).