In the simple model, which symbol represents the arterial drug concentration delivering to tissue?

In the simple model, which symbol represents the arterial drug concentration delivering to tissue?

• A. Cv
• B. Ct
• C. Vt
• D. Ca

Answer: (D)

The arterial drug concentration delivering to tissue is the concentration in arterial blood, Ca. In a simple model, tissue receives drug from the arterial supply, so this arterial concentration acts as the driving input for distribution—the rate at which drug is delivered to tissue is proportional to arterial flow times Ca. The other symbols correspond to different things: Cv is the venous concentration leaving the tissue, Ct is the concentration inside the tissue itself, and Vt is the tissue volume. Thus Ca correctly represents the arterial input driving delivery to tissue.

The arterial drug concentration delivering to tissue is the concentration in arterial blood, Ca. In a simple model, tissue receives drug from the arterial supply, so this arterial concentration acts as the driving input for distribution—the rate at which drug is delivered to tissue is proportional to arterial flow times Ca. The other symbols correspond to different things: Cv is the venous concentration leaving the tissue, Ct is the concentration inside the tissue itself, and Vt is the tissue volume. Thus Ca correctly represents the arterial input driving delivery to tissue.